There is not much factual information available at this point regarding the issue of growth hormone testing and therapy. In the meantime, growth in CdLS can be monitored by using the CdLS specific growth charts. If growth is below the lower curve, then other factors may need to be taken into account (e.g. growth hormone deficiency). Several cases of growth hormone deficiency have been documented, probably higher than the incidence in the unaffected population, but this has not been studied carefully. Certainly with documented growth hormone deficiency, replacement hormone may be appropriate.