Most babies with de Lange Syndrome have frequent chest infections and are usually difficult feeders. In many cases these problems are either caused or worsened by gastroesophageal reflux and improve when it is treated. The few children with the syndrome that have very serious and complicated abnormalities of the hear may die before they are five years old. However, most children and adults with the syndrome are fit and healthy and, from the information that we have at the present time, we have no reason to believe that they will not survive to the same age as their brothers and sisters. It is unlikely that individuals with the classical de Lange Syndrome will be able to live independently or have a job but adults with the mild de Lange Syndrome may be able to live on their own and have jobs in sheltered workshops.